diff --git a/experimental/CHANGELOG.md b/experimental/CHANGELOG.md
index 4f553c1bd97..8221fefec22 100644
--- a/experimental/CHANGELOG.md
+++ b/experimental/CHANGELOG.md
@@ -14,6 +14,7 @@ For notes on migrating to 2.x / 0.200.x see [the upgrade guide](doc/upgrade-to-2
 
 ### :bug: Bug Fixes
 
+* fix(instrumentation-xhr): resolve relative URLs before matching `ignoreUrls` [#6551](https://github.com/open-telemetry/opentelemetry-js/pull/6551) @Maximiliano-Zeballos
 * fix(sdk-node): fix setting of ViewOption#name from ConfigurationModel [#6620](https://github.com/open-telemetry/opentelemetry-js/pull/6620) @trentm
 * fix(web-common): add limit for timeout [#6601](https://github.com/open-telemetry/opentelemetry-js/pull/6601) @maryliag
 
diff --git a/experimental/packages/opentelemetry-instrumentation-xml-http-request/src/xhr.ts b/experimental/packages/opentelemetry-instrumentation-xml-http-request/src/xhr.ts
index 16d82a73100..55270cefa70 100644
--- a/experimental/packages/opentelemetry-instrumentation-xml-http-request/src/xhr.ts
+++ b/experimental/packages/opentelemetry-instrumentation-xml-http-request/src/xhr.ts
@@ -371,13 +371,13 @@ export class XMLHttpRequestInstrumentation extends InstrumentationBase<XMLHttpRe
     url: string,
     method: string
   ): api.Span | undefined {
-    if (isUrlIgnored(url, this.getConfig().ignoreUrls)) {
+    const parsedUrl = parseUrl(url);
+    if (isUrlIgnored(parsedUrl.href, this.getConfig().ignoreUrls)) {
       this._diag.debug('ignoring span as url matches ignored url');
       return;
     }
 
     let name = '';
-    const parsedUrl = parseUrl(url);
     const attributes = {} as api.Attributes;
     if (this._semconvStability & SemconvStability.OLD) {
       name = method.toUpperCase();
diff --git a/experimental/packages/opentelemetry-instrumentation-xml-http-request/test/xhr.test.ts b/experimental/packages/opentelemetry-instrumentation-xml-http-request/test/xhr.test.ts
index b4b780741be..b1bb817042e 100644
--- a/experimental/packages/opentelemetry-instrumentation-xml-http-request/test/xhr.test.ts
+++ b/experimental/packages/opentelemetry-instrumentation-xml-http-request/test/xhr.test.ts
@@ -755,6 +755,19 @@ describe('xhr', () => {
           });
         });
 
+        describe('when relative url is ignored via domain regex', () => {
+          beforeEach(done => {
+            clearData();
+            prepareData(done, '/xml-http-request.js', {
+              propagateTraceHeaderCorsUrls: [/.*/],
+              ignoreUrls: [/.*localhost.*/],
+            });
+          });
+
+          it('should NOT create any span', () => {
+            assert.ok(exportSpy.notCalled, "span shouldn't be exported");
+          });
+        });
         describe('when clearTimingResources is set', () => {
           beforeEach(done => {
             clearData();