diff --git a/cirq-google/cirq_google/serialization/circuit_serializer.py b/cirq-google/cirq_google/serialization/circuit_serializer.py
index 7835cfaeea7..20e4232a8f0 100644
--- a/cirq-google/cirq_google/serialization/circuit_serializer.py
+++ b/cirq-google/cirq_google/serialization/circuit_serializer.py
@@ -260,7 +260,9 @@ def _serialize_gate_op(
                 msg.fsimgate.translate_via_model = True
         elif isinstance(gate, cirq.MeasurementGate):
             arg_func_langs.arg_to_proto(gate.key, out=msg.measurementgate.key)
-            arg_func_langs.arg_to_proto(gate.invert_mask, out=msg.measurementgate.invert_mask)
+            if len(gate.invert_mask):
+                # Do not serialize empty invert mask until servers support empty tuples
+                arg_func_langs.arg_to_proto(gate.invert_mask, out=msg.measurementgate.invert_mask)
         elif isinstance(gate, cirq.WaitGate):
             arg_func_langs.float_arg_to_proto(
                 gate.duration.total_nanos(), out=msg.waitgate.duration_nanos