diff --git a/compiler/rustc_mir_transform/src/ref_prop.rs b/compiler/rustc_mir_transform/src/ref_prop.rs
index dafd2ae23a635..d1bc9ee91538e 100644
--- a/compiler/rustc_mir_transform/src/ref_prop.rs
+++ b/compiler/rustc_mir_transform/src/ref_prop.rs
@@ -85,7 +85,9 @@ fn propagate_ssa<'tcx>(tcx: TyCtxt<'tcx>, body: &mut Body<'tcx>) {
     let ssa = SsaLocals::new(body);
 
     let mut replacer = compute_replacement(tcx, body, &ssa);
-    debug!(?replacer.targets, ?replacer.allowed_replacements, ?replacer.storage_to_remove);
+    debug!(?replacer.targets);
+    debug!(?replacer.allowed_replacements);
+    debug!(?replacer.storage_to_remove);
 
     replacer.visit_body_preserves_cfg(body);
 
@@ -190,8 +192,11 @@ fn compute_replacement<'tcx>(
             continue;
         }
 
+        // Whether the current local is subject to the uniqueness rule.
+        let needs_unique = ty.is_mutable_ptr();
+
         // If this a mutable reference that we cannot fully replace, mark it as unknown.
-        if ty.is_mutable_ptr() && !fully_replacable_locals.contains(local) {
+        if needs_unique && !fully_replacable_locals.contains(local) {
             debug!("not fully replaceable");
             continue;
         }
@@ -203,13 +208,14 @@ fn compute_replacement<'tcx>(
             // have been visited before.
             Rvalue::Use(Operand::Copy(place) | Operand::Move(place))
             | Rvalue::CopyForDeref(place) => {
-                if let Some(rhs) = place.as_local() {
+                if let Some(rhs) = place.as_local() && ssa.is_ssa(rhs) {
                     let target = targets[rhs];
-                    if matches!(target, Value::Pointer(..)) {
+                    // Only see through immutable reference and pointers, as we do not know yet if
+                    // mutable references are fully replaced.
+                    if !needs_unique && matches!(target, Value::Pointer(..)) {
                         targets[local] = target;
-                    } else if ssa.is_ssa(rhs) {
-                        let refmut = body.local_decls[rhs].ty.is_mutable_ptr();
-                        targets[local] = Value::Pointer(tcx.mk_place_deref(rhs.into()), refmut);
+                    } else {
+                        targets[local] = Value::Pointer(tcx.mk_place_deref(rhs.into()), needs_unique);
                     }
                 }
             }
@@ -217,10 +223,10 @@ fn compute_replacement<'tcx>(
                 let mut place = *place;
                 // Try to see through `place` in order to collapse reborrow chains.
                 if place.projection.first() == Some(&PlaceElem::Deref)
-                    && let Value::Pointer(target, refmut) = targets[place.local]
+                    && let Value::Pointer(target, inner_needs_unique) = targets[place.local]
                     // Only see through immutable reference and pointers, as we do not know yet if
                     // mutable references are fully replaced.
-                    && !refmut
+                    && !inner_needs_unique
                     // Only collapse chain if the pointee is definitely live.
                     && can_perform_opt(target, location)
                 {
@@ -228,7 +234,7 @@ fn compute_replacement<'tcx>(
                 }
                 assert_ne!(place.local, local);
                 if is_constant_place(place) {
-                    targets[local] = Value::Pointer(place, ty.is_mutable_ptr());
+                    targets[local] = Value::Pointer(place, needs_unique);
                 }
             }
             // We do not know what to do, so keep as not-a-pointer.
@@ -276,16 +282,35 @@ fn compute_replacement<'tcx>(
                 return;
             }
 
-            if let Value::Pointer(target, refmut) = self.targets[place.local]
-                && place.projection.first() == Some(&PlaceElem::Deref)
-            {
-                let perform_opt = (self.can_perform_opt)(target, loc);
-                if perform_opt {
-                    self.allowed_replacements.insert((target.local, loc));
-                } else if refmut {
-                    // This mutable reference is not fully replacable, so drop it.
-                    self.targets[place.local] = Value::Unknown;
+            if place.projection.first() != Some(&PlaceElem::Deref) {
+                // This is not a dereference, nothing to do.
+                return;
+            }
+
+            let mut place = place.as_ref();
+            loop {
+                if let Value::Pointer(target, needs_unique) = self.targets[place.local] {
+                    let perform_opt = (self.can_perform_opt)(target, loc);
+                    debug!(?place, ?target, ?needs_unique, ?perform_opt);
+
+                    // This a reborrow chain, recursively allow the replacement.
+                    //
+                    // This also allows to detect cases where `target.local` is not replacable,
+                    // and mark it as such.
+                    if let &[PlaceElem::Deref] = &target.projection[..] {
+                        assert!(perform_opt);
+                        self.allowed_replacements.insert((target.local, loc));
+                        place.local = target.local;
+                        continue;
+                    } else if perform_opt {
+                        self.allowed_replacements.insert((target.local, loc));
+                    } else if needs_unique {
+                        // This mutable reference is not fully replacable, so drop it.
+                        self.targets[place.local] = Value::Unknown;
+                    }
                 }
+
+                break;
             }
         }
     }
@@ -326,18 +351,23 @@ impl<'tcx> MutVisitor<'tcx> for Replacer<'tcx> {
     }
 
     fn visit_place(&mut self, place: &mut Place<'tcx>, ctxt: PlaceContext, loc: Location) {
-        if let Value::Pointer(target, _) = self.targets[place.local]
-            && place.projection.first() == Some(&PlaceElem::Deref)
-        {
-            let perform_opt = matches!(ctxt, PlaceContext::NonUse(_))
-                || self.allowed_replacements.contains(&(target.local, loc));
-
-            if perform_opt {
-                *place = target.project_deeper(&place.projection[1..], self.tcx);
-                self.any_replacement = true;
+        if place.projection.first() != Some(&PlaceElem::Deref) {
+            return;
+        }
+
+        loop {
+            if let Value::Pointer(target, _) = self.targets[place.local] {
+                let perform_opt = matches!(ctxt, PlaceContext::NonUse(_))
+                    || self.allowed_replacements.contains(&(target.local, loc));
+
+                if perform_opt {
+                    *place = target.project_deeper(&place.projection[1..], self.tcx);
+                    self.any_replacement = true;
+                    continue;
+                }
             }
-        } else {
-            self.super_place(place, ctxt, loc);
+
+            break;
         }
     }
 
diff --git a/tests/mir-opt/reference_prop.mut_raw_then_mut_shr.ReferencePropagation.diff b/tests/mir-opt/reference_prop.mut_raw_then_mut_shr.ReferencePropagation.diff
new file mode 100644
index 0000000000000..af8ee2411d36d
--- /dev/null
+++ b/tests/mir-opt/reference_prop.mut_raw_then_mut_shr.ReferencePropagation.diff
@@ -0,0 +1,74 @@
+- // MIR for `mut_raw_then_mut_shr` before ReferencePropagation
++ // MIR for `mut_raw_then_mut_shr` after ReferencePropagation
+  
+  fn mut_raw_then_mut_shr() -> (i32, i32) {
+      let mut _0: (i32, i32);              // return place in scope 0 at $DIR/reference_prop.rs:+0:30: +0:40
+      let mut _1: i32;                     // in scope 0 at $DIR/reference_prop.rs:+1:9: +1:14
+      let mut _4: *mut i32;                // in scope 0 at $DIR/reference_prop.rs:+3:16: +3:36
+      let mut _5: &mut i32;                // in scope 0 at $DIR/reference_prop.rs:+3:16: +3:26
+      let _8: ();                          // in scope 0 at $DIR/reference_prop.rs:+7:5: +7:26
+      let mut _9: i32;                     // in scope 0 at $DIR/reference_prop.rs:+8:6: +8:7
+      let mut _10: i32;                    // in scope 0 at $DIR/reference_prop.rs:+8:9: +8:10
+      scope 1 {
+          debug x => _1;                   // in scope 1 at $DIR/reference_prop.rs:+1:9: +1:14
+          let _2: &mut i32;                // in scope 1 at $DIR/reference_prop.rs:+2:9: +2:13
+          scope 2 {
+              debug xref => _2;            // in scope 2 at $DIR/reference_prop.rs:+2:9: +2:13
+              let _3: *mut i32;            // in scope 2 at $DIR/reference_prop.rs:+3:9: +3:13
+              scope 3 {
+                  debug xraw => _3;        // in scope 3 at $DIR/reference_prop.rs:+3:9: +3:13
+                  let _6: &i32;            // in scope 3 at $DIR/reference_prop.rs:+4:9: +4:13
+                  scope 4 {
+                      debug xshr => _6;    // in scope 4 at $DIR/reference_prop.rs:+4:9: +4:13
+                      let _7: i32;         // in scope 4 at $DIR/reference_prop.rs:+6:9: +6:10
+                      scope 5 {
+                          debug a => _7;   // in scope 5 at $DIR/reference_prop.rs:+6:9: +6:10
+                          scope 6 {
+                          }
+                      }
+                  }
+              }
+          }
+      }
+  
+      bb0: {
+          StorageLive(_1);                 // scope 0 at $DIR/reference_prop.rs:+1:9: +1:14
+          _1 = const 2_i32;                // scope 0 at $DIR/reference_prop.rs:+1:17: +1:18
+-         StorageLive(_2);                 // scope 1 at $DIR/reference_prop.rs:+2:9: +2:13
+          _2 = &mut _1;                    // scope 1 at $DIR/reference_prop.rs:+2:16: +2:22
+          StorageLive(_3);                 // scope 2 at $DIR/reference_prop.rs:+3:9: +3:13
+-         StorageLive(_4);                 // scope 2 at $DIR/reference_prop.rs:+3:16: +3:36
+-         StorageLive(_5);                 // scope 2 at $DIR/reference_prop.rs:+3:16: +3:26
+-         _5 = &mut (*_2);                 // scope 2 at $DIR/reference_prop.rs:+3:16: +3:26
+-         _4 = &raw mut (*_5);             // scope 2 at $DIR/reference_prop.rs:+3:16: +3:26
++         _4 = &raw mut _1;                // scope 2 at $DIR/reference_prop.rs:+3:16: +3:26
+          _3 = _4;                         // scope 2 at $DIR/reference_prop.rs:+3:16: +3:36
+-         StorageDead(_5);                 // scope 2 at $DIR/reference_prop.rs:+3:36: +3:37
+-         StorageDead(_4);                 // scope 2 at $DIR/reference_prop.rs:+3:36: +3:37
+          StorageLive(_6);                 // scope 3 at $DIR/reference_prop.rs:+4:9: +4:13
+-         _6 = &(*_2);                     // scope 3 at $DIR/reference_prop.rs:+4:16: +4:22
++         _6 = &_1;                        // scope 3 at $DIR/reference_prop.rs:+4:16: +4:22
+          StorageLive(_7);                 // scope 4 at $DIR/reference_prop.rs:+6:9: +6:10
+-         _7 = (*_6);                      // scope 4 at $DIR/reference_prop.rs:+6:13: +6:18
+-         StorageLive(_8);                 // scope 5 at $DIR/reference_prop.rs:+7:5: +7:26
+-         (*_3) = const 4_i32;             // scope 6 at $DIR/reference_prop.rs:+7:14: +7:23
+-         _8 = const ();                   // scope 6 at $DIR/reference_prop.rs:+7:5: +7:26
+-         StorageDead(_8);                 // scope 5 at $DIR/reference_prop.rs:+7:25: +7:26
++         _7 = _1;                         // scope 4 at $DIR/reference_prop.rs:+6:13: +6:18
++         _1 = const 4_i32;                // scope 6 at $DIR/reference_prop.rs:+7:14: +7:23
+          StorageLive(_9);                 // scope 5 at $DIR/reference_prop.rs:+8:6: +8:7
+          _9 = _7;                         // scope 5 at $DIR/reference_prop.rs:+8:6: +8:7
+          StorageLive(_10);                // scope 5 at $DIR/reference_prop.rs:+8:9: +8:10
+          _10 = _1;                        // scope 5 at $DIR/reference_prop.rs:+8:9: +8:10
+          _0 = (move _9, move _10);        // scope 5 at $DIR/reference_prop.rs:+8:5: +8:11
+          StorageDead(_10);                // scope 5 at $DIR/reference_prop.rs:+8:10: +8:11
+          StorageDead(_9);                 // scope 5 at $DIR/reference_prop.rs:+8:10: +8:11
+          StorageDead(_7);                 // scope 4 at $DIR/reference_prop.rs:+9:1: +9:2
+          StorageDead(_6);                 // scope 3 at $DIR/reference_prop.rs:+9:1: +9:2
+          StorageDead(_3);                 // scope 2 at $DIR/reference_prop.rs:+9:1: +9:2
+-         StorageDead(_2);                 // scope 1 at $DIR/reference_prop.rs:+9:1: +9:2
+          StorageDead(_1);                 // scope 0 at $DIR/reference_prop.rs:+9:1: +9:2
+          return;                          // scope 0 at $DIR/reference_prop.rs:+9:2: +9:2
+      }
+  }
+  
diff --git a/tests/mir-opt/reference_prop.read_through_raw.ReferencePropagation.diff b/tests/mir-opt/reference_prop.read_through_raw.ReferencePropagation.diff
index a7d505c69066b..75c1f8f57ccae 100644
--- a/tests/mir-opt/reference_prop.read_through_raw.ReferencePropagation.diff
+++ b/tests/mir-opt/reference_prop.read_through_raw.ReferencePropagation.diff
@@ -9,15 +9,14 @@
       let mut _5: *mut usize;              // in scope 0 at $SRC_DIR/core/src/intrinsics/mir.rs:LL:COL
   
       bb0: {
-          _2 = &mut (*_1);                 // scope 0 at $DIR/reference_prop.rs:+10:13: +10:25
+-         _2 = &mut (*_1);                 // scope 0 at $DIR/reference_prop.rs:+10:13: +10:25
 -         _3 = &mut (*_2);                 // scope 0 at $DIR/reference_prop.rs:+11:13: +11:26
 -         _4 = &raw mut (*_2);             // scope 0 at $DIR/reference_prop.rs:+12:13: +12:30
 -         _5 = &raw mut (*_3);             // scope 0 at $DIR/reference_prop.rs:+13:13: +13:30
 -         _0 = (*_4);                      // scope 0 at $DIR/reference_prop.rs:+15:13: +15:22
 -         _0 = (*_5);                      // scope 0 at $DIR/reference_prop.rs:+16:13: +16:22
-+         _3 = &mut (*_1);                 // scope 0 at $DIR/reference_prop.rs:+11:13: +11:26
-+         _0 = (*_2);                      // scope 0 at $DIR/reference_prop.rs:+15:13: +15:22
-+         _0 = (*_3);                      // scope 0 at $DIR/reference_prop.rs:+16:13: +16:22
++         _0 = (*_1);                      // scope 0 at $DIR/reference_prop.rs:+15:13: +15:22
++         _0 = (*_1);                      // scope 0 at $DIR/reference_prop.rs:+16:13: +16:22
           return;                          // scope 0 at $DIR/reference_prop.rs:+17:13: +17:21
       }
   }
diff --git a/tests/mir-opt/reference_prop.rs b/tests/mir-opt/reference_prop.rs
index e3e5d791464eb..93f8d1df8e85a 100644
--- a/tests/mir-opt/reference_prop.rs
+++ b/tests/mir-opt/reference_prop.rs
@@ -433,6 +433,29 @@ fn maybe_dead(m: bool) {
     )
 }
 
+fn mut_raw_then_mut_shr() -> (i32, i32) {
+    let mut x = 2;
+    let xref = &mut x;
+    let xraw = &mut *xref as *mut _;
+    let xshr = &*xref;
+    // Verify that we completely replace with `x` in both cases.
+    let a = *xshr;
+    unsafe { *xraw = 4; }
+    (a, x)
+}
+
+fn unique_with_copies() {
+    let y = {
+        let mut a = 0;
+        let x = &raw mut a;
+        // `*y` is not replacable below, so we must not replace `*x`.
+        unsafe { opaque(*x) };
+        x
+    };
+    // But rewriting as `*x` is ok.
+    unsafe { opaque(*y) };
+}
+
 fn main() {
     let mut x = 5_usize;
     let mut y = 7_usize;
@@ -444,6 +467,8 @@ fn main() {
     multiple_storage();
     dominate_storage();
     maybe_dead(true);
+    mut_raw_then_mut_shr();
+    unique_with_copies();
 }
 
 // EMIT_MIR reference_prop.reference_propagation.ReferencePropagation.diff
@@ -454,3 +479,5 @@ fn main() {
 // EMIT_MIR reference_prop.multiple_storage.ReferencePropagation.diff
 // EMIT_MIR reference_prop.dominate_storage.ReferencePropagation.diff
 // EMIT_MIR reference_prop.maybe_dead.ReferencePropagation.diff
+// EMIT_MIR reference_prop.mut_raw_then_mut_shr.ReferencePropagation.diff
+// EMIT_MIR reference_prop.unique_with_copies.ReferencePropagation.diff
diff --git a/tests/mir-opt/reference_prop.unique_with_copies.ReferencePropagation.diff b/tests/mir-opt/reference_prop.unique_with_copies.ReferencePropagation.diff
new file mode 100644
index 0000000000000..2cda2409e8093
--- /dev/null
+++ b/tests/mir-opt/reference_prop.unique_with_copies.ReferencePropagation.diff
@@ -0,0 +1,66 @@
+- // MIR for `unique_with_copies` before ReferencePropagation
++ // MIR for `unique_with_copies` after ReferencePropagation
+  
+  fn unique_with_copies() -> () {
+      let mut _0: ();                      // return place in scope 0 at $DIR/reference_prop.rs:+0:25: +0:25
+      let _1: *mut i32;                    // in scope 0 at $DIR/reference_prop.rs:+1:9: +1:10
+      let mut _2: i32;                     // in scope 0 at $DIR/reference_prop.rs:+2:13: +2:18
+      let _4: ();                          // in scope 0 at $DIR/reference_prop.rs:+5:18: +5:28
+      let mut _5: i32;                     // in scope 0 at $DIR/reference_prop.rs:+5:25: +5:27
+      let _6: ();                          // in scope 0 at $DIR/reference_prop.rs:+9:14: +9:24
+      let mut _7: i32;                     // in scope 0 at $DIR/reference_prop.rs:+9:21: +9:23
+      scope 1 {
+          debug y => _1;                   // in scope 1 at $DIR/reference_prop.rs:+1:9: +1:10
+          scope 5 {
+          }
+      }
+      scope 2 {
+          debug a => _2;                   // in scope 2 at $DIR/reference_prop.rs:+2:13: +2:18
+          let _3: *mut i32;                // in scope 2 at $DIR/reference_prop.rs:+3:13: +3:14
+          scope 3 {
+              debug x => _3;               // in scope 3 at $DIR/reference_prop.rs:+3:13: +3:14
+              scope 4 {
+              }
+          }
+      }
+  
+      bb0: {
+          StorageLive(_1);                 // scope 0 at $DIR/reference_prop.rs:+1:9: +1:10
+          StorageLive(_2);                 // scope 0 at $DIR/reference_prop.rs:+2:13: +2:18
+          _2 = const 0_i32;                // scope 0 at $DIR/reference_prop.rs:+2:21: +2:22
+-         StorageLive(_3);                 // scope 2 at $DIR/reference_prop.rs:+3:13: +3:14
+          _3 = &raw mut _2;                // scope 2 at $DIR/reference_prop.rs:+3:17: +3:27
+          StorageLive(_4);                 // scope 3 at $DIR/reference_prop.rs:+5:9: +5:30
+          StorageLive(_5);                 // scope 4 at $DIR/reference_prop.rs:+5:25: +5:27
+          _5 = (*_3);                      // scope 4 at $DIR/reference_prop.rs:+5:25: +5:27
+          _4 = opaque::<i32>(move _5) -> bb1; // scope 4 at $DIR/reference_prop.rs:+5:18: +5:28
+                                           // mir::Constant
+                                           // + span: $DIR/reference_prop.rs:452:18: 452:24
+                                           // + literal: Const { ty: fn(i32) {opaque::<i32>}, val: Value(<ZST>) }
+      }
+  
+      bb1: {
+          StorageDead(_5);                 // scope 4 at $DIR/reference_prop.rs:+5:27: +5:28
+          StorageDead(_4);                 // scope 3 at $DIR/reference_prop.rs:+5:30: +5:31
+          _1 = _3;                         // scope 3 at $DIR/reference_prop.rs:+6:9: +6:10
+-         StorageDead(_3);                 // scope 2 at $DIR/reference_prop.rs:+7:5: +7:6
+          StorageDead(_2);                 // scope 0 at $DIR/reference_prop.rs:+7:5: +7:6
+          StorageLive(_6);                 // scope 1 at $DIR/reference_prop.rs:+9:5: +9:26
+          StorageLive(_7);                 // scope 5 at $DIR/reference_prop.rs:+9:21: +9:23
+-         _7 = (*_1);                      // scope 5 at $DIR/reference_prop.rs:+9:21: +9:23
++         _7 = (*_3);                      // scope 5 at $DIR/reference_prop.rs:+9:21: +9:23
+          _6 = opaque::<i32>(move _7) -> bb2; // scope 5 at $DIR/reference_prop.rs:+9:14: +9:24
+                                           // mir::Constant
+                                           // + span: $DIR/reference_prop.rs:456:14: 456:20
+                                           // + literal: Const { ty: fn(i32) {opaque::<i32>}, val: Value(<ZST>) }
+      }
+  
+      bb2: {
+          StorageDead(_7);                 // scope 5 at $DIR/reference_prop.rs:+9:23: +9:24
+          StorageDead(_6);                 // scope 1 at $DIR/reference_prop.rs:+9:26: +9:27
+          _0 = const ();                   // scope 0 at $DIR/reference_prop.rs:+0:25: +10:2
+          StorageDead(_1);                 // scope 0 at $DIR/reference_prop.rs:+10:1: +10:2
+          return;                          // scope 0 at $DIR/reference_prop.rs:+10:2: +10:2
+      }
+  }
+