Some plugins leverage playhead information to perform audio processing tasks.

Right now the only Python tool with this capability that I am aware of is DawDreamer: https://github.com/DBraun/DawDreamer

Playhead code: https://github.com/search?q=repo%3ADBraun%2FDawDreamer+AudioPlayHead&type=code&

However, the tool is not as friendly to use as Pedalboard and one requires to add significant amount of code to do simple tasks.