Release 2.7 with updates to support https://reseek.online

Add features to support database search web site https://reseek.online

Release 2.6.1 with bug fixes and improved E-value estimates

Implement new model accounting for filter effects in large databases.
Fix -alignpair bug for long structures.
Fix threshold bug causing hits with high E-values to be included in the output.

Release 2.5 better scaling with small queries/very large databases

Resolved bottleneck with smaller queries against AFDB50 by adding -db_mu option to support pre-calculated Mu FASTA for the database.

Release 2.4 improved scaling for very large databases

Revised Mu prefilter step of -fast mode to use two-hit instead of single-hit seeding, this gives much better speed for AFDB searches.

Release 2.3 resolves scaling issues in release 2.2

With release 2.3, 100 full-length proteins can be searched against AFDB50 (size 200M folds) on a 32-core Linux server in 3 hours using 12 Gb RAM.

Release 2.1

Updated mega files for compatibility with Muscle 5.3. For making multiple structure alignments, use Reseek v2.1 + Muscle v5.3.

Release 2.0.2

Improved speed & memory use (this build used for minor revision of paper).

Release 2.0.1

Minor update adding AQ support. AQ is an alignment quality metric similar to TM score with better sensitivity to homologs than TM.

Release 2.0

Updated E-value calculation with substantially improved sensitivity.

Version 1.2

Supports generating .mega files and distance matrices for Muscle-3D multiple structure alignment.