The problem
You have to restart the bot and modify its config file to change the blacklist.
The solution
We could make the URL blacklist available from IRC and editable.
https://github.com/Pix1234/ZppixBot-Source/blob/master/modules/urls.py does this and could be inspiration
Edit: in particular, this bit here https://github.com/Pix1234/ZppixBot-Source/blob/master/modules/urls.py#L242-L289